Overview of Picked Chemical Compounds and Intermediates
Overview of Picked Chemical Compounds and Intermediates
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1. Pharmaceutical Intermediates
Bortezomib Acid Impurity: This can be an impurity connected to bortezomib, a proteasome inhibitor used in the remedy of a number of myeloma. Its synthesis or examine is vital for ensuring the purity and basic safety in the drug.
Abiraterone Acetate Intermediate (CAS NO. 122111-01-7): A precursor while in the synthesis of abiraterone acetate, a drug used in the treatment of prostate cancer by inhibiting androgen manufacturing.
Imatinib Intermediate (CAS NO. 152460-ten-1): A important compound in the synthesis of imatinib, a drug that targets unique sorts of cancer, which includes chronic myelogenous leukemia (CML).
Docetaxel Intermediate: A compound Utilized in the synthesis of docetaxel, a chemotherapy medication that treats numerous cancers for instance breast, lung, and prostate cancer.
two. Chemical Impurities and Byproducts
GeMcitabine Intermediates (T6, T9, eight): These are definitely intermediates inside the synthesis of gemcitabine, an anti-most cancers drug. Their examine is vital for optimizing the production approach and making sure higher purity.
Lapatinib Intermediate (CAS NO. 231278-eighty four-5): Lapatinib is used to deal with breast most cancers, and these intermediates are involved with its production.
Fulvestrant Intermediates: Fulvestrant can be an estrogen receptor antagonist used in the treatment method of breast most cancers. Numerous intermediates help in the synthesis of this drug.
Paclitaxel Aspect Chain Acid (CAS NO. 949023-sixteen-nine): This intermediate is used in the synthesis of paclitaxel, a chemotherapy drug productive in treating cancers for example ovarian, breast, and lung most cancers.
three. Other Noteworthy Compounds
Irinotecan Hydrochloride Trihydrate (CAS NO. 136572-09-3): A chemotherapy drug used in the treatment method of colorectal cancer and 7-dihydro-4-oxo-1H-pymol[2 compact mobile lung cancer.
three-Amino-one-hydroxyadamantane (CAS 702-eighty two-nine): This compound is linked to the synthesis of adamantane derivatives, which have a variety of purposes, together with antiviral Qualities.
Vildagliptin Intermediates: Employed in the production of vildagliptin, an oral drug for variety 2 diabetes that inhibits the enzyme DPP-4 to regulate blood sugar ranges.
4. Miscellaneous Compounds
D-Gluconic Acid δ-Lactone (CAS NO. 61259-48-1): This compound is involved in the synthesis of assorted gluconic acid derivatives, which might be Utilized in foodstuff, pharmaceutical, and industrial apps.
Canagliflozin Intermediate two: A precursor while in 17b)-7-(9-Bromononyl)-estra-1 the synthesis of canagliflozin, a medication utilised to control variety 2 diabetes by inhibiting sodium-glucose co-transporter two (SGLT2).